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Wednesday, July 1, 2020

what is the major product of the following intramolecular aldol reaction

  Dr. Supriya       Wednesday, July 1, 2020

what is the major product of the following intramolecular aldol reaction


what is the major product of the following intramolecular aldol reaction

An aldol condensation is a reaction between two carbonyl compounds at least one which must have one or more alpha hydrogens in it. The reaction is catalyzed by acid or base with the formation of enol or enolate of one carbonyl group. The so formed enol or enolate then makes a nucleophilic attack on the other carbonyl compond and a new carbon-carbon bond is formed. On protonation, it forms a beta-hydroxy carbonyl compound which on heating converts into alpha-beta unsaturated carbonyl compound with the elimination of water.

what is the major product of the following intramolecular aldol reaction

When both the carbonyl groups are present on the same compound the aldol reaction occurs within the same molecule and that is known as intramolecular aldol reaction. It is to be noted that always a cyclic compound is produced out of an intramolecular aldol reaction. The major product of an aldol reaction is triggered by acidity of alpha hydrogen to the carbonyl and the ring strain of the formed product.

how to find the major product of the intramolecular aldol reaction
 

what is the major product of the following intramolecular aldol reaction

what is the major product of the following intramolecular aldol reaction
Find the major products

what is the major product of the following intramolecular aldol reaction

The solutions of the above problem are explained in this following YouTube video:




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